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butabarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of CYP3A4 inducers could lessen sufentanil levels and efficacy, potentially precipitating withdrawal syndrome in people who've designed Bodily dependence to sufentanil. Discontinuation of concomi